Interestingly, the melanoma cell lines considered in this study included tumors bearing BRAFV600E mutation (IR6 and FOR) and BRAF wild-type (VAG, 1007, MUL, LOJ), but the observed 1α-OH-vitD3 mediated-biological effects on cell proliferation and tumor growth occurred independently by the BRAF status. The potential functional role of vitamin-D in triggering tumor cell differentiation and/or senescence also deserves consideration. The gene discussed is BRAF; the disease is melanoma.