Some authors have investigated biological data for use as prognostic factors in neuroendocrine tumour (NET) and NEC patients, and these have included lactate dehydrogenase (LDH)3, 4, CgA3, 4, neuron-specific enolase (NSE)4, platelets, haemoglobin, white blood cell count, alkaline phosphatase (ALP), and C-reactive protein (CRP)3. This evidence concerns the gene CRP and neuroendocrine neoplasm.