ESR2 and atherosclerosis: For instances, ESR1 and ESR2 mediate the vascular system to promote the functional recovery of vascular injury and provide neuroprotective effects in central neural system34; PTGS1 and PTGS2 contribute to atherosclerosis and thrombosis by regulating the production of eicosanoids that modulate physiological processes in the vessel wall35; JUN modulates smooth muscle cell proliferation in response to vascular angioplasty36; additionally, ICAM1 mediates the adhesion of neutrophils and monocytes to vascular endothelium37.