Several functions associated with cluster headache are related to the brain, including “Calcium-release channel activity” (P = 0.0083), “Ganglioside metabolic process” (P = 0.0025) and Reactome pathways “GABA receptor activation” (P = 0.0066) and “Inhibition of voltage gated Ca2+channels via Gbeta/gamma subunits” (P = 0.0074) (Table 4). The gene discussed is SUCLG2; the disease is Cluster headache.