SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: We identified 2 recurrent mutations (c.311 C>T, p.Ala104Val and c.181 C>T, p.Leu61Phe) in SCN1A gene (http://www.ncbi.nlm.nih.gov/clinvar), a known epilepsy gene for Dravet syndrome (DS), generalized epilepsy with febrile seizures plus (GEFS+) and epileptic encephalopathy14, 15, 16.