Previous studies have evaluated for prognostic biomarkers in esophageal adenocarcinoma in a variety of cancer‐related pathways including VEGF/angiogenesis, cell cycle pathways, cell free circulating microRNAs, DNA repair pathways, and a few studies have evaluated the role of SNPs in miRNA pathways in the risk of esophageal cancer and on esophageal squamous cell carcinoma prognosis, but no studies to date have evaluated the role of polymorphisms in miRNA pathway genes on esophageal adenocarcinoma prognosis 9, 21, 22, 23, 24, 25, 26, 27. This evidence concerns the gene VEGFA and esophageal squamous cell carcinoma.