Aberrant expression of epidermal growth factor receptor (EGFR) and/or the ligand-independent EGFR mutant EGFRvIII (a product of a genetic deletion resulting in loss of exons 2-7 in the mRNA) is a frequent phenomenon in glioblastoma [26, 60], driving growth and migration of tumor cells [141]. The gene discussed is EGFR; the disease is glioblastoma.