TNF and CAPN5-related vitreoretinopathy: Recent experimental studies have reported finding increased levels of inflammatory cytokines such as monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor α (TNFα) increased in the detached retina, which indicates that inflammatory reactions may modify the pathogenesis of the photoreceptor damage and the proliferative vitreoretinopathy (PVR) in RRD [1, 2].