The analysis of NOTCH1 mutations in patients from the German CLL8 trial suggests that CLL patients harboring NOTCH1 mutations may not benefit from the addition of rituximab to fludarabine and cyclophosphamide, indicating that NOTCH1 may also become a predictive marker of response to rituximab in CLL [15]. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.