It was reported that CYP1A1*2C increase the overall risk of NSCLC with an odd ratio of 2.88 (95% CI = 1.70–5.00, p < 0.001) [38], in accordance with our results in which CYP1A1*4 and *2C associated with increased risk of NSCLC by 2 times. This evidence concerns the gene CYP1A1 and non-small cell lung carcinoma.