For CYP2E1*6 Dra I (D/C) polymorphism, a significantly increased BC risk in the overall population was found in genetic model D/C vs. D/D (OR = 1.29, 95% CI = 1.04–1.61, P = 0.023) and C/C + D/C vs. D/D (OR = 1.25, 95% CI = 1.04–1.51, P = 0.019), together with subjects who have at least one C allele (C vs. D: OR = 1.46, 95% CI = 1.20–1.79, P < 0.001). The gene discussed is CYP2E1; the disease is breast cancer.