EGF and neoplasm: The epidermal growth factor (EGF); family members of fibroblast growth factor (FGF); VEGF; matrix metalloproteinases (MMPs); heparanase; plasmin, activator of the urokinase-type plasminogen (uPA); the uPA receptor; and cytokines and chemokines as TGF-β, which enlarge the inflammatory state, are among the key related factors secreted by TAMs in the tumor microenvironment [21, 25, 28].