The first occurs directly by oncogenes such as Ras and Myc that can increase the expression of angiogenic factors in cancer cells, while, in second, the angiogenic signals are indirectly produced by inflammatory cells, specially TAMs [21] that play a crucial role in tumor promotion and progression, contributing to neovascularization and tumor cell proliferation and metastasis [24–27]. Here, MYC is linked to neoplasm.