TSC2 and neoplasm: Gene mutations such as oncogenes and tumor suppressor genes confer constitutive activation of the mTOR pathway in conditions of nutrient depletion increasing its expression in various types of cancer, such as AKT in breast and ovarian cancer, PI3K in ovarian, gastrointestinal, breast, and prostate cancer, TSC1/TSC2 in the hamartomas formation and lymphangioleiomyomatosis development [63].