Interestingly, infection of MEFs with Salmonella did not show significant differences in bacterial numbers at 1.5 h, 5 h, or 24 h, indicating that pml+/+ and pml−/− MEFs are similarly sensitive to Salmonella entry and replication and thereby confirming our in vivo data and PML’s specificity toward Listeria (Fig. 1C; see also Fig. S1A). This evidence concerns the gene PML and infection.