Xenotransplantation of HCT116 p53+/+ cells infected with pLPC-JMJD2B-overexpressing retroviral construct (Figure 7A) into immunocompromised mice resulted in a significant increase in tumor growth relative to pPLC-empty-vector-infected cells (Figure 7B and Supplementary Figure S6A). Here, KDM4B is linked to neoplasm.