TP53 and neoplasm: Conversely, no significant difference was observed in subcutaneous growth (Figure 7F) and tumor weight (Supplementary Figure S6B) of pLPC(EV) and pLPC-JMJD2B HCT116 p53−/− cells, thus indicating that JMJD2B exerts a strong tumor-promoting effect in a p53-dependent manner.