TP53 and neoplasm: To further confirm the importance of JMJD2B for tumor maintenance in vivo, we injected HCT116 p53+/+ cells stably transfected with either two different shRNA hairpins against JMJD2B (shJMJD2B-2 and shJMJD2B-4) or hairpin targeting a control protein (shGFP) into the dorsal flanks of SCID hairless mice (Figure 7G).