Also, JMJD2C, another member of the JMJD2 family, originally identified as a ‘gene amplified in squamous cell carcinoma 1’ (GASC1), is amplified and overexpressed in several tumor types, including breast cancer (46), esophageal squamous cell carcinoma (47), metastatic sarcomatoid carcinoma of the lung (48), primary mediastinal B cell lymphoma and Hodgkin lymphoma (49). This evidence concerns the gene KDM4A and esophageal squamous cell carcinoma.