In line with these observations, evidence has emerged that the JMJD2/KDM4 subfamily of demethylases is highly expressed in several tumor types and, specifically, JMJD2B expression levels appears to be increased in breast, colorectal, gastric, prostate, lung and bladder malignancies (13–18,43–45). The gene discussed is KDM4B; the disease is neoplasm.