MAPT and Classical progressive supranuclear palsy: The tau pathology made up of the hyperphosphorylated tau is also a hallmark of several neurodegenerative disorders known as tauopathies, including frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, Pick disease, parkinsonism-dementia complex of Guam, and chronic traumatic encephalopathy.