Thus, in the present experiments, we explored the effects of SJZD on TNBS-induced colitis rat model, then we investigated TEER, permeability, expression of TJs and NF-κB signaling way of TNBS-damaged Caco2 cells monolayer, further to figure out intestinal barrier protective effect and mechanism of SJZD. Here, NFKB1 is linked to colitis.