TP53 and colorectal carcinoma: Given the higher number of karyotypic alterations in CRC with co-occurrence of BCL9L and TP53 alterations (Figure 1E) and our results showing a BCL9L survival effect in TP53-WT and null backgrounds (Figures 3D, 3E, S4C, and S4D), we investigated a potential p53-independent role for BCL9L in aneuploidy tolerance.