TP53 mutations occur frequently in aneuploid tumors (Cianchi et al., 1999, Rowan et al., 2005, Tang et al., 2004); however, next-generation sequencing efforts have not specifically explored the somatic mutational landscapes of aneuploid versus diploid MSS CRC tumors to identify determinants of CIN. Here, TP53 is linked to colorectal carcinoma.