The LDL receptor related protein 1B (LRP1B, rs2890652), Potassium voltage-gated channel subfamily J member 11 (KCNJ11, rs5219), CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1, rs7754840) and Fat mass and obesity (FTO, rs11642841) gene polymorphisms were associated with pre-pregnancy BMI at suggestive levels (Table 4). This evidence concerns the gene CDKAL1 and obesity due to melanocortin 4 receptor deficiency.