The LOC646736 locus and its relation to insulin resistance was characterized and authors suggested clear genotype effects on insulin signaling in skeletal muscle, however did not argue for causality of IRS1. Additional pathology might be possible, either via the translation of LOC646736 transcripts, however due to the lack of putative protein expression identification in human tissues, it is possible that LOC646736 transcripts are linc (long intergenic non-coding) RNAs that alter insulin signal transduction by either cis or trans regulation [41]. This evidence concerns the gene IRS1 and Insulin resistance.