Furthermore, in a recent study with early intervention (diet, lifestyle intervention from the 13th gw) applied in high GDM risk individuals (BMI>30kg/m2) only non-carriers of the risk allele G benefited from the 3 months intervention assessed by PG values at routine OGTT suggesting that MTNR1B rs10830963 variant could modify the efficacy of lifestyle interventions [35]. Here, MTNR1B is linked to gestational diabetes.