Abnormal activation of PRC2 due to genetic mutations in its catalytic subunit EZH2 has been widely studied in lymphoma malignancy [1–7], which serves as the basis for targeting PRC2 as novel therapeutic approach in treating malignant cancers such as follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.