The rest of Ggppsfl/fl, Ddx4-Cre females showed a delayed first litter (day 78.7 ± 3.9 vs. 104.7 ± 8.7), reduced litter numbers (8.3 ± 0.4 vs. 2.3 ± 0.7) and the reduced litter size (6.6 ± 0.4 vs. 3.8 ± 0.6), and they eventually became infertile after 28 weeks (Fig 2A). Here, DDX4 is linked to Infertility.