The hypermethylated genes were enriched in the insulin signaling pathway (P = 0.0125), spliceosome (P = 0.0219), Notch signaling pathway (P = 0.0259), acute myeloid leukemia (P = 0.0394), and ErbB signaling pathway (P = 0.0467, S6 Table). Here, INS is linked to acute myeloid leukemia.