It was also reported that the antioxidant and anti-inflammatory drugs GVT (Graft Versus Tumor) or MSL (monosodium luminol) suppress ts1-induced oxidative stress by up-regulating the nuclear transcription factor NF-E2-related factor 2 (Nrf2) using a murine retrovirus ts1 mutant as a model for human immunodeficiency virus (HIV)-associated dementia [42]. Here, NFE2L2 is linked to dementia.