BACE1 and Alzheimer disease: The natural flavonoid compounds, named the EA-CG extract, which contained five phytochemicals that are the major constituents of Maysin (i.e., Luteolin, Isoorientin, Rhamnosylisoorientin, Derhamnosylmaysin, and Maysin) in which those are may represents a potential anti-BACE1 phytochemicals as non-pharmacological alternatives or diet regimen that could prevent AD-like pathological symptoms by reducing soluble β-amyloid production and inhibiting amyloid plaque formation [20].