In addition, two polyphenol components of pomegranate extract (punicalagin and ellagic acid) ameliorated the cognitive impairment, which may counteract the microglia activation and accelerated inflammation associated with the Aβ-induced pro-inflammatory cytokine, TNF-α, in (APP/PS1) transgenic AD mice [52]. The gene discussed is PSEN1; the disease is Cognitive impairment.