CDX2 and polyp: Cdx2 stimulates markers of enterocyte differentiation.[24] Null mutation of Cdx2 lead to the development of ectopic lesions with a gastric phenotype in the midgut endoderm.[25] The study present that mice in which Cdx2 gene had been inactivated developed multiple intestinal polyp-like lesions in the mouse esophagus and stomach.[26]