However, the percentages of CD223-positive CD8+ T lymphocytes among chronic hepatitis B patients with low ALT and low DNA (Group III) and low ALT and high DNA (Group IV) were not significantly different from the percentages observed in the HCs group (38.99 ± 15.44% and 34.09 ± 10.92% vs. 25.96 ± 16.27%, P = 0.051 and P = 0.097, respectively, Fig. 2). Here, LAG3 is linked to chronic hepatitis B virus infection.