EP300 and Cognitive impairment: In mice, inhibition of p300 activity significantly impairs fear memory consolidation, and associated neural plasticity in the lateral amygdala.30 P300 inhibition further induced enhanced anxiety and mild cognitive impairment in a water maze task.31 Altered emotional significance detection and maladaptive appraisal have been associated with amygdala dysfunction in schizophrenia before.32, 33, 34 Thus, previous evidence supports the potential relevance of the observed association, particularly as we were able to replicate our result in an independent sample (Figure 3).