Besides association with schizophrenia, mutations in the EP300 gene are responsible for the Rubinstein-Taybi syndrome, a developmental disorder that includes intellectual disability, impulsivity, distractibility and mood instability.29EP300 encodes p300, a protein that functions as histone-acetyltransferase and is expressed in the brain in limbic and cortical regions. The gene discussed is EP300; the disease is Rubinstein-Taybi syndrome.