CACNA1C and schizophrenia: In our own previous work we were able to identify potential intermediate phenotypes8, 9 in five RDoC subdomains (working memory (WM), episodic memory, reward processing (RP), social cognition and emotion processing) that were modulated by risk variants within schizophrenia-associated variants (for example, CACNA1C, ZNF804A).10, 11, 12, 13 Importantly, several of these findings were successfully replicated in independent samples.14, 15, 16