CDX2 and neoplasm: Interestingly, notwithstanding the data above showing that the ANXA10 protein was strongly expressed in human serrated morphology CRC and mouse Cdx2−/− BrafV600E serrated tumor epithelium, it was still a surprise that Anxa10 was the top activated gene in the Cdx2−/− BrafV600E-mutant epithelium (Figure 5B).