To further explore the usefulness of the CDX2Null/BRAFV600E-mutant organoids as a model system, we studied the gene expression by q-RT PCR for the top 15 genes showing positive interaction of CDX2 silencing and BRAFV600E expression in mouse colon tissues and five more ‘up’ genes that are shared by our mouse data-set and one of the two human CRC data sets – the TCGA data-set or the Finish data-set (Figure 5—source data 3, marked as red). This evidence concerns the gene CDX2 and colorectal carcinoma.