LRIG1 and neoplasm: We studied Cdx2-mutant, BrafV600E-mutant, and Cdx2 BrafV600E double-mutant, as well as Apc-mutant mouse colon epithelium, for expression of transcripts for various intestinal stem cell markers and Wnt pathway genes, such as: Olfm4, Lgr5, Msi1, Cd133, Lrig1, Nkd1, Hopx, Bmi1, Cd44, Axin2, Mmp7, Ephb2, cMyc and Sox9. Compared to control colon tissues, only Olfm4, Mmp7 and Sox9 expression were markedly increased in tumor tissues from the CDX2P-CreERT2 Cdx2fl/fl BrafCA mice (Figure 3—figure supplement 2A and B).