EGFR and colorectal carcinoma: Consistent with a previous study showing that EGFR activation was found in majority of CRC cell lines harboring BRAFV600E mutation (Prahallad et al., 2012), the tumors arising in the TAM-treated CDX2P-CreERT2 Cdx2fl/fl BrafCAmice showed significant higher levels of phospho-EGFR expression, compared to very low level of phospho-EGFR in Cdx2−/−-mutant, BrafV600E-mutant, or normal control mouse cecal epithelium (Figure 4).