We found that combined TAM-mediated targeting of an Apcflallele together with the Cdx2fl and BrafCA alleles in CDX2P-CreERT2 Cdx2fl/fl BrafCA Apcfl/+ mice did not alter the histology of the tumor lesions compared to those arising in CDX2P-CreERT2 Cdx2fl/fl BrafCAmice with intact Apc alleles (Figure 2—figure supplement 1E). The gene discussed is APC; the disease is neoplasm.