Besides BRAF mutations, other features more commonly seen in CDX2-negative tumors were CIMP-H status (p=0.04); membranous staining for β-catenin throughout the tumor, including the invasive front, likely reflecting wild type status for Wnt pathway genes (e.g, APC and CTNNB1, encoding β-catenin) (p=0.05); and retention of p16INK4A expression (p=0.04) (Table 1 and Figure 1). The gene discussed is CDKN2A; the disease is neoplasm.