The median survival of mice with simultaneous targeting of one Apcfl allele together with Cdx2fl and BrafCA alleles was 158 days, indicating that inactivation of one Apc allele did not enhance tumor aggressiveness compared to the phenotype seen in CDX2P-CreERT2 Cdx2fl/fl BrafCA mice (Figure 2A). The gene discussed is APC; the disease is neoplasm.