TP53 and breast carcinoma: To further confirm that p73 plays a role in BITC-mediated p53-pathway activation, growth-inhibition and apoptosis-induction in p53-mutant breast cancer cells, we silenced p73 using siRNA or overexpressed p73 using HA-p73 overexpression construct (HA-p73 O/E) in MDA-MB-231 cells.