Forty of the 260 genes can be categorized as DNA methylation, tumor suppressor, activated signaling, myeloid transcriptional factor, chromatin modifier, and spliceosome; these genes and NPM1 are involved in the leukemogenesis and previous studies showed that most of them might be associated with the prognosis of AML patients (Fig. 1)3, 15. This evidence concerns the gene NPM1 and acute myeloid leukemia.