Furthermore, through adoptive transfer of myelin oligodendrocyte glycoprotein (MOG)35-55 loaded Tofa-DCs to the mice with established experimental autoimmune encephalomyelitis (EAE), Th17 cells from splenocytes of treated mice decreased significantly and Tregs increased by contrast, while a reduction in disease severity and progression was observed. This evidence concerns the gene OMG and experimental autoimmune encephalomyelitis.