NR1H4 and Acute hepatitis: In models of acute hepatitis mediated by Con A and α-GalCer, farnesoid X receptor (FXR) activation drives the accumulation of MDSCs to liver via upregulation of S100A8 and augments the suppressive function of MDSCs through upregulation of receptor paired immunoglobulin-like receptor B (PIR-B) by binding the PIR-B promoter [132].