It was found that LPS improved TNF-α, macrophage inflammatory protein-alpha (MIP-1α), MCP-1, and cytokine-induced neutrophil chemoattractant 1 (CINC-1) in KCs-SV40, whereas TNF-α upregulated CINC-1, IFN-γ-inducible protein 10 (IP-10), and MIP-2 expression in H4IIEC3 hepatoma cells in a dose-dependent matter. Here, TNF is linked to hepatocellular carcinoma.