Adipose tissue imbalances caused by obesity induce ectopic fat accumulation in the liver, leading to NAFLD; furthermore, these imbalances increase secretion of proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin- (IL-) 6 and reduce the secretion of anti-inflammatory factors such as IL-10 and adiponectin [22]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.