Our data reveal that CD44-positive expression in ovarian cancers were significantly associated with a high TMN stage (pooled OR = 2.11, 95% CI 1.26–3.53, P = 0.004) and poor 5-year overall survival (RR = 1.42, 95% CI 1.01–2.00, P = 0.05). Here, CD44 is linked to ovarian cancer.