Forced expression of TFF3 decreased mRNA expression of BAX, TIMP2, CDKN2A, SERPINB5 and CDH1, but increased mRNA levels of CDH2, VIM, TGFB1, TERT, SERPINE1, TWIST, KI67, SURVIVIN, MMP2 and MMP3 which closely correlated with increasing cell cycle progression, anti-apoptosis, proliferation, metastasis and invasion of cervical cancer cells [9, 10, 28, 29]. The gene discussed is MMP3; the disease is cervical cancer.