SIRT1 and neoplasm: Sirtuin1 (SIRT1) is a NAD+-dependent deacetylase, mainly deacetylating histones and many nonhistone targets, including p53, FoxO1, FoxO3, Atg5, Atg7, Atg8, Ku70, NF-κB, and PTEN, and is involved in tumor development, energy homeostasis, autophagy, DNA damage repair, and other important cellular processes [17].