BECN1 and neoplasm: As presented in Table 1, high Beclin-1/high SIRT1 expression was also associated with tumor size (p = 0.002), histological grade (p = 0.001), LN metastasis (p < 0.001), tumor invasion (p = 0.026), TNM stage (p < 0.001), and VCE (p = 0.030).