SIRT1 and neoplasm: Of these characteristics, large tumor size (>5 cm) (OR = 7.211, 95% CI 1.382–37.632), and high SIRT1 expression (OR = 4.617, 95% CI 1.416–15.053) were independently associated with high Beclin-1 expression, while only high Beclin-1 expression (OR = 7.818, 95% CI 1.987–30.756) was independently associated with high SIRT1 expression in GC (Table 2).