Furthermore, high Beclin-1 expression has been shown to be a poor prognostic factor in ovarian cancer [10], nasopharyngeal carcinoma [13], but a favorable prognostic factor in GC [11, 12], intrahepatic cholangiocarcinoma [14], hepatocellular carcinoma [15] and colorectal cancer [16]. This evidence concerns the gene BECN1 and hepatocellular carcinoma.