ANGPT1 and atherosclerosis: The mechanisms by which Ang-1 promotes atherosclerosis appear to involve (i) Ang-1-induced pro-remodelling cytokine release; (ii) Ang-1 increases the proportion of circulating inflammatory monocytes and (iii) Ang-1-mediated reduction in CD11b expression on monocytes, resulting in increased monocyte/macrophage retention in atherosclerotic plaques.