In order to further confirm the effects of Ang1 in atherosclerosis development without the confounding effects of western diet on inflammation in apoE-/- mice, AdAng-1 or control AdEV were injected in apoE-/- mice fed a normal chow diet and en face analyses of Sudan IV-stained areas in thoracic aortas were quantified 4 weeks after treatment. Here, APOE is linked to atherosclerosis.