NGFR and desmoplastic melanoma: It has previously been show that cells expressing NGFR represent an intermediate in the process by which melanocytes differentiate from neural crest cells (Mica et al, 2013) and NGFR is used clinically as a histopathological marker to distinguish desmoplastic melanomas, tumors that are negative for conventional melanocytic markers, from other skin neoplasms (Lazova et al, 2010).