Initial case-control analyses showed that IgG antibodies to V1/V2 inversely correlated with risk of HIV-1 infection but in vaccinees with high levels of Env-specific IgA, IgG avidity, antibody-dependent cellular cytotoxicity (ADCC), Nab, and Env-specific CD4+ T cells, there was no correlation between these variables and infection [13]. The gene discussed is CD4; the disease is HIV-1 infection.