ERVW-1 and infection: HIV-1 subtype C (HIV-1C) is responsible for 50% of infections globally [25], and we have previously described the development of a candidate vaccine regimen comprising of two multigene recombinant vaccines, a DNA vaccine (DNA-C) and an MVA vaccine (MVA-C), expressing matched HIV-1C proteins (Gag, RT, Tat, Nef, Env) [26], [27], [28].