CD8A and cystic fibrosis: However, there was a significant difference in lymphoid follicle composition in female CF patients as B cells were less abundant (p = 0.043), whereas CD8 T cells were more abundant (p = 0.0029) than in male CF patients, resulting in a CD20-CD4-CD8 distribution of 52%–39%–9% respectively in males, and 34%–39%–27% respectively in females (Fig. 3b).