The presence of cytoplasmic inclusions containing aggregated forms of the presynaptic protein α-synuclein (aSyn) is characteristic of a panel of neurodegenerative diseases commonly referred to as synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy [49]. This evidence concerns the gene SNCA and Lewy body dementia.