FLCN and Renal neoplasm: However, no clear genotype–phenotype associations between FLCN mutation type or location and skin, lung, or renal manifestations have been identified to date; only a significantly lower frequency of renal neoplasia has been reported in patients with a deleted cytosine in the exon 11 mutational “hot spot” compared with the patients with an inserted cytosine at this location [15, 16].