To demonstrate whether Fbw7 promotes apoptosis through regulating Stat3, siRNA of Stat3, plasmids of Fbw7 and Stat3 was transfected as instructed in ABC-DLBCL cell lines, using Doxorubicin to induce apoptosis and staining with Annexin-V-PE followed by flow cytometry analysis. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.