SERPING1 and hereditary angioedema: We did not find significant differences among the stress responses as measured with the Rahe’s Brief Stress and Coping Inventory tests in patients diagnosed with C1-INH-HAE, in angioedematous patients (without C1-INH deficiency), and healthy controls, using the Kruskal-Wallis one-way analysis of variance test (p = 0.1725).