Finally, our interaction analysis showing that a change in the L/A ratio throughout pregnancy and at follow-up was associated with a larger increase in the TG/HDL-C, as well as the LDL/HDL-C and apoB/apoA ratio, supports that the L/A ratio may be of particular relevance in GDM and enhance the adverse effects of glucose intolerance on CV risk. The gene discussed is APOB; the disease is Glucose intolerance.