Our main findings were: (1) The L/A ratio was higher in GDM women both during pregnancy and follow-up compared to non-GDM women (2) a high L/A ratio during pregnancy was associated with CV risk based on unfavorable lipid ratios at follow-up, especially the TG/HDL-C ratio (3) interaction analysis indicated that an increase in the L/A ratio of 1 unit was associated with a higher CV risk in GDM compared to normal pregnancy (4) low adiponectin levels independently predicted unfavorable lipid ratios at follow-up. The gene discussed is ADIPOQ; the disease is gestational diabetes.