Most of the WT1 mutations occur mainly in exon 8 and 9, which code for zinc finger domains 2 and 3, respectively which can lead to isolated SRNS, two distinct clinical syndromes that are associated with SRNS (1) Denys-Drash syndrome (DDS) (2) Frasier syndrome (FS), and conditions without Nephrotic syndrome such as Wilm’s tumor, Meacham syndrome and somatic Mesothelioma (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/omim database). The gene discussed is WT1; the disease is Wilms tumor.