Inhibition of HDAC activity may occur in human colon cancer lines, with an increase in histone H3 acetylation in global or local histone modification status, such as induction of TRAIL, DR4 and Fas-L, p21 genes, via histone acetyltransferase (HAT) p300/CBP [35, 36]. This evidence concerns the gene CREBBP and malignant colon neoplasm.