In this study, we evaluated CIL-102-induced apoptosis and the cell cycle arrest G2/M phase in human DLD-1 cancer cells as a result of the expression of p21 and GADD45 and cdc2/cyclin B inactivation by the activation of the JNK1/2 signaling pathway and the p50NF-κB/p300/CBP pathway. The gene discussed is CREBBP; the disease is cancer.