Although previous studies suggest that CsA prevents the synthesis and secretion of interleukins [98, 99] and TNF-α [100], and blocks VEGF-induced angiogenesis [99, 101, 102], the mechanisms involved in CsA-mediated inhibition of MMP expression and pterygium fibroblast migration have not been completely elucidated. This evidence concerns the gene VEGFA and pterygium.