EMT is a highly conserved developmental program that allows polarized, immotile epithelial cells to convert to those with motile mesenchymal properties.27 Recently, accumulating data indicated that EMT has an important role in tumor metastasis.4, 28, 29 Most importantly, Xiang et al.11 reported that during TGFβ-induced EMT, Grhl2 is downregulated and Grhl2 is always downregulated in cells that had undergone EMT. This evidence concerns the gene GRHL2 and neoplasm.