Overall, our data strongly support a model in which germline BRCA2-mutant PCa are genotypically-similar to mCRPC and frequently harbour genomic aberrations in key pathways (for example, WNT/APC, IL6-BMP6, mTOR, ATR, MYCN, and so on; Supplementary Data 6; Fig. 4c) leading to genomic instability, NED, castrate-resistance and metastasis, together explaining adverse patient prognosis. Here, BRCA2 is linked to posterior cortical atrophy.