To identify other driver events that might help explain the aggressiveness of BRCA2-mutant PCa, we investigated the amplification of a region on chromosome 3q (Fig. 1b) that is common in BRCA2-mutant PCa (11/18; 61%), but rare in sporadic PCa (55/809; 6.8% P=1.64 × 10−9, two-sided proportion test). This evidence concerns the gene BRCA2 and posterior cortical atrophy.