Importantly, the MED12L homolog, MED12 (chromosome Xq13.1), is amplified in 44% of BRCA2-mutant PCa specimens (8/18) compared with only ∼0.1% of localized sporadic PCa (1/809, P=3.64 × 10−44, two-sided proportion test). Here, BRCA2 is linked to posterior cortical atrophy.