Although the TMPRSS2:ERG gene fusion on chromosome 21 was observed at similar frequencies in BRCA2-mutant and sporadic PCa (Fig. 2a; 3/12 versus 68/200; P=0.74, proportion test; Supplementary Table 1), we identified several GRs in BRCA2-mutant PCa (Fig. 2b; Supplementary Fig. 7; Supplementary Data 2). Here, TMPRSS2 is linked to posterior cortical atrophy.