Consistent with their alteration at the copy-number and methylation levels in aggressive BRCA2-mutant PCa, MED12/MED12L are also amplified and/or show elevated RNA expression levels in 18% (26/150) of mCRPC6 but only 7.5% (25/333) of sporadic, localized PCa18 (P=0.002, proportion test). This evidence concerns the gene MED12 and posterior cortical atrophy.