Genomic changes associated with aggressive disease were more common, including gain of the MYC oncogene, which occurred in 72% (13/18) of BRCA2-mutant PCa which was significantly higher than the 20.1% rate in sporadic PCa of equivalent Gleason score (57/283; P=1.42 × 10−3; two-sided proportion test17. Here, MYC is linked to posterior cortical atrophy.