Supplementary Data 1 lists all genes with differential rates of copy-number aberrations. No individual gene was altered by SNVs in more than one BRCA2-mutant patient (Supplementary Fig. 4). In fact, of the 11 most frequently mutated genes in a cohort of 477 sporadic localized PCa (ref. 13), only 1 was mutated in BRCA2-mutant PCa: TP53 (Supplementary Fig. 5). Similarly of the 32 genes mutated in at least two BRCA2-mutant PCa, only 12 were mutated in 477 sporadic PCa. One BRCA2-mutant PCa harboured a kataegic event (Supplementary Fig. 6). Here, TP53 is linked to posterior cortical atrophy.