In this study, to identify the drivers of aggression in BRCA2-mutant PCa, we characterized genomic alterations in localized PCa tumour specimens from 14 men carrying a deleterious germline mutant BRCA2 allele using either whole-genome sequencing (WGS) and/or SNP array-based copy-number analyses (CNAs). Here, BRCA2 is linked to posterior cortical atrophy.