BRCA2 and posterior cortical atrophy: Overall ∼1% (4,979/435,377) of copy-number neutral probes showed differential methylation between BRCA2-mutant and sporadic PCa specimens (Supplementary Data 3), and 74% (3,677/4,979) of these were hypomethylated, including 21 of the 25 most differentially methylated genes (Supplementary Fig. 11).