Interestingly, it was noted that kaempferol or chrysin treatments and their combination significantly attenuated serum TNF-α and NO levels when these cytokines were majorly expressed in the septic animal at the early phase of sepsis, followed by a general depletion of their concentrations in all groups at a later phase, which is attributed to the short lifespan of these cytokines. The gene discussed is TNF; the disease is Sepsis.