IL17A and Arthritis: From a mechanistic point of view, Xuzhu and colleagues demonstrated, in the mouse collagen-induced arthritis model, that either prophylactic or therapeutic administration of resveratrol attenuated clinical arthritis parameters and bone erosions, and was associated with reduced serum levels of pro-inflammatory cytokines and collagen-specific IgG, reduced number of Th17 cells and of IL-17 in draining lymph nodes.